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Cassiopeia is a terrifying creature that can manipulate others to its will. Cassiopeia is a terrifying creature that can manipulate others to its will. As the youngest child, and also the most beautiful, of the Du Couteau family of Noxus, she penetrated the deep catacombs beneath Shurima to search for ancient power. There, she was bitten by a tomb guard and injected with venom that turned her into a half-human, half-snake. Cunning and swift, Cassiopeia now slithers through the night, petrifying her enemies with her terrifying gaze.